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From a market perspective, bromine's solubility profile makes it indispensable in certain niches where chlorine underperforms—particularly in high-temperature water treatment for cooling towers and oilfield drilling fluids. The 2025 price spike is forcing buyers to evaluate whether brominated biocides can be replaced by chlorine dioxide or non-oxidizing biocides. So far, substitution has been limited because bromine's efficacy in alkaline conditions remains unmatched.