PROTEASE Price — China Factory EXW 2026

PROTEASE price Spec: China national standards

China EXW, VAT excluded

Newest China EXW USD 1,486.73 / MT · VAT excluded unchanged as of 20210323

Newest Price 1,486.73

Price Date 20210323

Day's Change 0

Day's Range 1,486.73 - 1,486.73

Month's Change +470.8

Month's Range 1,486.73 - 1,957.52

Year's Change +693.21

Year's Range 1,486.73 - 793.51

Beyond detergents, nattokinase—a subtilisin-family enzyme from Bacillus subtilis natto—is gaining traction in China's health supplement market for thrombolytic claims. This creat...

Also known as endoproteinase asp-N from pseudomonas*fragi (muta, Endoproteinase Asp-N, ExcisionGrade, Pseudomonas fragi, Fungal Acid Protease, Neutral Protease froM Bacillus polyMyxa(Purified)

Opinions

How is protease (subtilisin) used in detergents and what drives its demand in China?

Beyond detergents, nattokinase—a subtilisin-family enzyme from Bacillus subtilis natto—is gaining traction in China's health supplement market for thrombolytic claims. This creates a separate, higher-margin demand pool. Importers should note that nattokinase products require strict customs clearance, including label pre-approval and product standard analysis, which can add lead time and cost.

How is directed evolution changing the competitive landscape for protease producers?

For buyers, the practical takeaway is to evaluate enzyme suppliers not just on price per kilogram but on performance consistency and customization capability. A supplier with in-house directed evolution can adjust enzyme profiles to match your specific process conditions—like pH, temperature, or substrate type—which often yields better cost-in-use than sourcing cheaper, generic enzymes that require higher dosing.

What are the key differences between industrial subtilisin and pharmaceutical-grade protease applications?

Another pharma-adjacent angle is PCSK9, a subtilisin/kexin-type protease that regulates LDL cholesterol. Monoclonal antibodies targeting PCSK9 can cut LDL-C by up to 70%, making them blockbuster lipid-lowering drugs. This is not a direct market for subtilisin itself, but it shows how subtilisin-family biology drives high-value therapeutic innovation, which could influence investor sentiment across enzyme-related stocks.

PROTEASE price context

What drives PROTEASE prices

How is protease (subtilisin) used in detergents and what drives its demand in China?: Beyond detergents, nattokinase—a subtilisin-family enzyme from Bacillus subtilis natto—is gaining traction in China's health supplement market for thrombolyti...

How is directed evolution changing the competitive landscape for protease producers?: For buyers, the practical takeaway is to evaluate enzyme suppliers not just on price per kilogram but on performance consistency and customization capability. A...

How we assess PROTEASE price

China factory / mainstream market EXW quotes (VAT excluded where shown) - not a single global public index

Regional and specification detail so buyers can compare like-for-like grades

Landed cost figures from our calculator are planning estimates, not a customs ruling

Overview

Protease (subtilisin, CAS 9001-92-7) is a serine protease enzyme produced by Bacillus subtilis, appearing as a powder or liquid preparation. It is widely used for protein hydrolysis across detergent, food, cosmetic, and health product applications.

Detergents: added to laundry powders and dishwashing liquids to break down protein-based stains.
Food processing: used in dairy production and meat tenderisation to modify protein structures.
Cosmetics: incorporated into skincare formulations for gentle exfoliation and oil control.
Health supplements: nattokinase, a subtilisin variant, is marketed for fibrinolytic and circulatory support.
Contact lens care: included in cleaning solutions to remove protein deposits.

China's production landscape centres on fermentation-derived subtilisin, with dominant grades for industrial detergent use and higher-purity enzyme preparations for food and cosmetic applications. The market includes both domestic supply and imported specialty enzymes, with growing interest in directed-evolution strains for enhanced activity in organic solvents.

Key domestic producers:
Bi zhi yan – self-developed dual-enzyme complex for cosmetic use.
Chinese Academy of Sciences Tianjin Institute – joint development of high-performance Bacillus subtilis strains.

Properties

Name

PROTEASE

endoproteinase asp-N from pseudomonas*fragi (muta

Endoproteinase Asp-N, ExcisionGrade, Pseudomonas fragi

Fungal Acid Protease

Neutral Protease froM Bacillus polyMyxa(Purified)

CAS Number

9001-92-7

EINECS No.

232-990-7

Risk Codes

S23;S24;S26;S36/37/39;S36/37;S22;S45

Safety Description

R37/38;R41;R42;R36/37/38

HS Code

3507900000

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