Phenacetin Price — China Factory EXW 2026

Phenacetin price Spec: China national standards

China EXW, VAT excluded

Newest China EXW USD 9,610.62 / MT · VAT excluded unchanged as of 20210322

Newest Price 9,610.62

Price Date 20210322

Day's Change 0

Day's Range 9,610.62 - 9,610.62

Month's Change -8,035.4

Month's Range 9,610.62 - 1,575.22

Year's Change +8,300.88

Year's Range 9,610.62 - 1,309.73

Watch sodium sulfide prices as a leading indicator for phenacetin quotes. The chemical's environmental footprint — high alkalinity and sulfide waste — is under scrutiny in China'...

Also known as 1-acetamido-4-ethoxybenzene, 1-ACETYL-P-PHENETIDIN, 4'-ethoxyacetanilide, 4-ACETOPHENETIDIDE

Opinions

How does phenacetin's synthesis chemistry and feedstock linkage to sodium sulfide affect its production cost and supply chain in China?

Watch sodium sulfide prices as a leading indicator for phenacetin quotes. The chemical's environmental footprint — high alkalinity and sulfide waste — is under scrutiny in China's green push. Any stricter effluent standards for sodium sulfide plants could tighten supply and lift phenacetin costs. Buyers should lock in contracts with integrated producers who control upstream sodium sulfide or p-nitrophenol supply.

What is the current market status of phenacetin-containing compound analgesics like Sudingpian in China, and how do regulations affect their trade?

The real trade risk is regulatory tightening. China's recent crackdowns on compound analgesic misuse and the global trend toward stricter nitrosamine impurity controls could force Sudingpian off the market entirely. Producers should diversify into paracetamol or other safer APIs, as phenacetin's legal window is narrowing. Export to Southeast Asian or African markets may offer short-term relief but carries reputational and compliance risks.

Why was phenacetin banned globally, and what does its regulatory history mean for current API trade and substitution demand?

The paracetamol substitution effect is the real market driver. As paracetamol remains the only widely used aniline analgesic, phenacetin demand is now almost entirely industrial — for dye intermediates and specialty synthesis. Chinese producers should monitor paracetamol supply tightness, as any disruption there could theoretically revive interest in phenacetin as a fallback intermediate, though regulatory barriers make large-scale revival unlikely.

Phenacetin price context

What drives Phenacetin prices

How does phenacetin's synthesis chemistry and feedstock linkage to sodium sulfide affect its production cost and supply chain in China?: Watch sodium sulfide prices as a leading indicator for phenacetin quotes. The chemical's environmental footprint — high alkalinity and sulfide waste — is unde...

What is the current market status of phenacetin-containing compound analgesics like Sudingpian in China, and how do regulations affect their trade?: The real trade risk is regulatory tightening. China's recent crackdowns on compound analgesic misuse and the global trend toward stricter nitrosamine impurity c...

How we assess Phenacetin price

China factory / mainstream market EXW quotes (VAT excluded where shown) - not a single global public index

Regional and specification detail so buyers can compare like-for-like grades

Landed cost figures from our calculator are planning estimates, not a customs ruling

Overview

Phenacetin (acetophenetidin, CAS 62-44-2) is a white crystalline powder with a melting point of 133–136 °C and very low water solubility. It is a synthetic aniline-derived analgesic and antipyretic that was among the first mass-produced synthetic drugs but has been withdrawn from most markets due to severe renal toxicity and carcinogenicity.

Pharmaceutical: historically used as an analgesic and antipyretic, often in combination formulations such as the now-banned compound analgesic tablet containing aminopyrine and caffeine.
Regulatory status: classified as a Group 1 carcinogen by the IARC since 2012; banned or withdrawn in the US, Europe, and many other countries since the 1960s–1980s.
Toxicology: its metabolites, including N-hydroxylated and nitroso compounds, are linked to analgesic nephropathy and urothelial tumors, distinguishing its toxicity profile from that of paracetamol.

China's production landscape is minimal, as the compound is no longer legally manufactured for pharmaceutical use domestically. Historical production was tied to paracetamol synthesis routes, but current relevance is limited to research or chemical reference standards.

Key domestic producers:
No active commercial producers identified in the reference material.

Properties

Name

Phenacetin

1-acetamido-4-ethoxybenzene

1-ACETYL-P-PHENETIDIN

4'-ethoxyacetanilide

4-ACETOPHENETIDIDE

CAS Number

62-44-2

EINECS No.

200-533-0

Risk Codes

S53;S45;S36/37;S26;S16

Safety Description

R45;R22;R20/21/22;R36;R11

HS Code

2924290000

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