cinobufagin Price — China Factory EXW 2026

cinobufagin price Spec: China national standards

China EXW, VAT excluded

Newest China EXW USD 2,338,769.91 / MT · VAT excluded unchanged as of 20210316

Newest Price 2,338,769.91

Price Date 20210316

Day's Change 0

Day's Range 2,338,769.91 - 2,338,769.91

Month's Change +11,660,601.77

Month's Range 2,338,769.91 - 13,999,371.68

Year's Change --

Year's Range --

Watch the downstream pharmaceutical sector closely. Cinobufagin's use in cardiotonic and anti-tumor formulations is expanding, but any regulatory change in TCM hospital procurement...

Also known as cinobufagin venom toad, (3beta,5beta,15beta,16beta)-16-(acetyloxy)-3-hydroxy-14,15-epoxybufa-20,22-dienolide, (3beta,5beta,8xi,9xi,10xi,13xi,14beta,15beta,16beta,17beta)-3-hydroxy-17-(2-oxo-2H-pyran-4-yl)-14,15-epoxyandrostan-16-yl acetate, 5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate

Opinions

What is driving the recent price surge for cinobufagin toad venom in Chinese herbal medicine markets?

Watch the downstream pharmaceutical sector closely. Cinobufagin's use in cardiotonic and anti-tumor formulations is expanding, but any regulatory change in TCM hospital procurement could alter demand elasticity. The thin trading volume means a single large order can move prices 5-10% within weeks.

Why does illegal harvesting of toad venom trigger criminal penalties, and how does this impact the legal supply of cinobufagin?

The regulatory crackdown is pushing the industry toward captive breeding. Unlike wild harvesting, farmed toads offer a traceable, legal supply source, though yields per animal remain low. Buyers should verify CITES and domestic permits when sourcing, as compliance costs are increasingly baked into premium pricing.

How does the toxicity and processing complexity of toad venom affect its market value and trade dynamics?

Quality verification is critical here. The toxin content assay is the key differentiator—material below 7.0% sells at a significant discount. Importers should insist on third-party HPLC testing, as visual inspection alone cannot distinguish potency levels, and substandard batches risk regulatory rejection.

cinobufagin price context

What drives cinobufagin prices

What is driving the recent price surge for cinobufagin toad venom in Chinese herbal medicine markets?: Watch the downstream pharmaceutical sector closely. Cinobufagin's use in cardiotonic and anti-tumor formulations is expanding, but any regulatory change in TCM ...

Why does illegal harvesting of toad venom trigger criminal penalties, and how does this impact the legal supply of cinobufagin?: The regulatory crackdown is pushing the industry toward captive breeding. Unlike wild harvesting, farmed toads offer a traceable, legal supply source, though yi...

How we assess cinobufagin price

China factory / mainstream market EXW quotes (VAT excluded where shown) - not a single global public index

Regional and specification detail so buyers can compare like-for-like grades

Landed cost figures from our calculator are planning estimates, not a customs ruling

Overview

Cinobufagin venom toad (蟾酥, CAS 470-37-1) is a dried secretion from the post-auricular and skin glands of the Asiatic toad, appearing as a yellowish-brown, glossy, translucent sheet or lump. It is a potent traditional Chinese medicinal material used for detoxification, pain relief, and resuscitation, with a melting point of 133°C and a density of 1.261 g/cm³.

Pharmaceutical: used in TCM formulations at a typical oral dose of 3–5 mg, with a maximum safe limit of 30 mg; overdose can cause severe toxicity.
Toxicology: contains bufadienolide compounds; toxicity is reduced by heat but not eliminated, and ingestion of 135 mg or more can cause serious poisoning.
Raw material: collected by squeezing the toad's glands, yielding only 0.015–0.02 g of dried product per toad per collection, making it a high-value, low-volume commodity.

China's production relies on manual collection from wild or farmed toads, with prices reaching tens of thousands of yuan per kilogram for pharmacopoeia-grade material. Harvesting is labour-intensive and legally restricted, as wild toads are protected; breeding and processing require permits. Market trends focus on selective breeding to enhance yield and core component content, such as cinobufagin and resibufogenin.

Key domestic producers:
Shandong Toad Breeding Base – integrated farming and venom extraction operations.

Properties

Name

cinobufagin

cinobufagin venom toad

(3beta,5beta,15beta,16beta)-16-(acetyloxy)-3-hydroxy-14,15-epoxybufa-20,22-dienolide

(3beta,5beta,8xi,9xi,10xi,13xi,14beta,15beta,16beta,17beta)-3-hydroxy-17-(2-oxo-2H-pyran-4-yl)-14,15-epoxyandrostan-16-yl acetate

5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate

CAS Number

470-37-1

EINECS No.

636-927-8

Risk Codes

S26;S36;S45;S36/37/39;S22;S24/25

Safety Description

R36/37/38;R26/27/28;R42/43;R20/22

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